According Trey Idekker, a pioneer in systems biology, explains systems biology as the use of data from genomic, proteomic and metabolomic technologies to construct mathematical models of complex biological systems and diseases. These approaches have recently become more powerful that requires tremendous skills in modeling techniques. So there is a need to provide a well rounded understanding of signalling networks, small scale genetic networks and its properties. This course aims to provide the understanding of the role of these networks and its implications in biological systems through the construction of simple mathematical models.